Dr. rer.-nat. Anne Wolf

Department of Ophthalmology
Experimental Immunology of the Eye
University Hospital Cologne
Joseph-Stelzmann-Str. 9
50931 Cologne, Germany
+49 221 478 84592
anne.wolf@uk-koeln.de

Projects:

Project leader

C06

Scientific career

Since 2015 Affiliated PhD student in Project 6 “Role of the complement system and microglia in age-related macular degeneration” in the DFG Research Unit FOR 2240 “Angiogenesis, Lymphangiogenesis and Cellular Immunity in Inflammatory Diseases of the Eye” at the Department of Ophthalmology, University of Cologne

2020Doctorate (“summa cum laude”) in Biology, University of Cologne, Prof. Dr. Thomas Langmann

Since 2020 Lab leader, Experimental Immunology of the Eye, University of Cologne

Since 2023 Co-PI CMMC-B07 Retinal microglia and their immunological effects in AAV-based ocular gene therapy

2024 PostDoc at the Maisonneuve-Rosemont Research Center, Université de Montréal, Canada. Prof. Przemyslaw (Mike) Sapieha.

Since 2024 PI in SFB 1607 “Towards immunomodulatory and anti(lymph)angiogenic therapies for age-related blinding eye diseases”.

Since 2024 PI in CAP (Career Advancement Program) Group 34 at CMMC (Center for Molecular Medicine Cologne)

Prizes and honors

2013 Top student, Bachelor of Science in Biology, University of Cologne

2015-2018 PhD Fellowship VELUX Foundation

2018 Pro Retina Travel Award

2019 IPaK Travel Award

2019 Retina Suisse Award

2020 German Research Award for Ophthalmology, Bayer (€50,000)

Since 2022 Editorial Board, Cellular Neuropathology (Frontiers in Cellular Neuroscience)

Since 2024 Gender Board Member SFB 1607

2024 Freifrau von Nauendorf Foundation Award (10,000 €)

Selected publications

  1. Hector, M., Behnke, V., Dabrowska-Schlepp, P., Busch, A., Schaaf, A. Langmann, T., Wolf, A. (2025) Moss‑derived human complement factor H modulates retinal immune response and attenuates retinal degeneration. J Neuroinflammation, doi: 10.1186/s12974-025-03418-2. Accepted and in press. Impact factor: 9.3. Corresponding author.
  2. Behnke, V., Wolf, A., Hector, M., Langmann, T. (2025) C3aR1-Deletion Delays Retinal Degeneration in a White-Light Damage Mouse Model. Invest Ophth Vis Sci 66, doi: 10.1167/iovs.66.1.15. Impact factor: 5.0
  3. Ciurus, S., Elewa, MAF., Palmer, MA,, Wolf, A., Hector, M., Fuhrmann, DC., Thomas, D., Gurke, R., Schwalm, MP., Berger, L., Zech, TJ., Burgers, LD., Marschalek, R., Geisslinger, G., Knapp, S., Langmann, T., Bracher. F., Weigert, A., Fürst, R. (2025) Inhibition of DYRK1B BY C81 impedes inflammatory processes in leukocytes by reducing STAT3 activity. Cell Mol Life Sci 82: 85, doi: 10.1007/s00018-025-05579-y. Impact factor: 6.2
  4. Zech TJ, Wolf A, Hector M, Bischoff-Kont I, Krishnathas GM, Kuntschar S, Schmid T, Bracher F, Langmann T, Fürst R (2024) 2-Desaza-annomontine (C81) impedes angiogenesis through reduced VEGFR2 expression derived from inhibition of CDC2-like kinases. Angiogenesis 27: 245-272, doi: 10.1007/s10456-024-09906-y. Impact factor: 9.2
  5. Hector, M., Langmann, T., Wolf, A. (2024) Translocator protein (18 kDa) (Tspo) in the retina and implications for ocular diseases. Prog Retin Eye Res 100: 101249, doi:10.1016/j.preteyeres.2024.101249. Impact factor: 18.7. Corresponding author.
  6. Diaz-Lezama N, Wolf A, Koch S, Pfaller AM, Biber J, Guillonneau X, Langmann T, Grosche A (2021) PDGF Receptor Alpha Signaling Is Key for Muller Cell Homeostasis Functions. Int J Mol Sci 22, doi: 10.3390/ijms22031174. Impact factor: 5.6
  7. Tabel M, Wolf A, Szczepan M, Xu H, Jagle H, Moehle C, Chen M, Langmann T (2022) Genetic targeting or pharmacological inhibition of galectin-3 dampens microglia reactivity and delays retinal degeneration. J Neuroinflammation 19: 229, doi: 10.1186/s12974-022-02589-6. Impact factor: 9.3
  8. Khan, A. S., Wolf, A. & Langmann, T. (2021). The AhR ligand 2, 2′-aminophenyl indole (2AI) regulates microglia homeostasis and reduces pro-inflammatory signaling. Biochem Biophys Res Commun, 579, 15-21, doi:10.1016/j.bbrc.2021.09.054. Impact factor: 2.5
  9. Wolf, A., Herb, M., Schramm, M., & Langmann, T. (2020). The TSPO-NOX1 axis controls phagocyte-triggered pathological angiogenesis in the eye. Nat Commun, 11(1), 2709. doi:10.1038/ s41467-020-16400-8. Impact factor: 14.91
  10. Kinuthia, U. M., Wolf, A., & Langmann, T. (2020). Microglia and Inflammatory Responses in Diabetic Retinopathy. Frontiers in Immunology, 11(2888). doi:10.3389/fimmu.2020.564077. Impact factor: 7.56
  11. Behnke, V., Wolf, A., Langmann, T. (2020). The role of lymphocytes and phagocytes in age- related macular degeneration (AMD). Cell Mol Life Sci, 77(5), 781-788. doi:10.1007/ s00018-019-03419-4. Impact factor: 9.26
  12. Wolf, A., & Langmann, T. (2019). Anti-VEGF-A/ANG2 combotherapy limits pathological angiogenesis in the eye: a replication study. EMBO Mol Med, 11(5). doi:10.15252/ emmm.201910362. Impact factor: 12.13
  13. Herb, M., Gluschko, A., Wiegmann, K., Farid, A., Wolf, A., Utermohlen, O., Krug, O., Krönke, M., Schramm, M. (2019). Mitochondrial reactive oxygen species enable proinflammatory signaling through disulfide linkage of NEMO. Sci Signal, 12(568). doi:10.1126/scisignal.aar5926. Impact factor: 8.19
  14. Balser, C.* and Wolf, A.*, Herb, M., & Langmann, T. (2019). Co-inhibition of PGF and VEGF blocks their expression in mononuclear phagocytes and limits neovascularization and leakage in the murine retina. J Neuroinflammation, 16(1), 26. doi:10.1186/s12974-019-1419-2. Impact factor: 8.32

Project-related Publications

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