Prof. Dr. phil. Manuel Koch

Institut für experimentelle Zahnmedizin und orale muskoloskeletale Biologie,
Zentrum für Biochemie
Universität zu Köln
Joseph-Stelzmann-Str. 52
50931 Köln
+49 176 43 66 95 32
manuel.koch@uni-koeln.de

Projekte:

Projektleiter

Z01

Wissenschaftliche Karriere

1995 Postdoktorand (Prof. Dr. Matthias Chiquet), Universität Bern, Schweiz

1996 – 1999 Postdoktorand, Research Fellow am Cutaneous Biology Research Center, Massachusetts General Hospital, Boston, USA (Prof. R.E. Burgeson)

1999 – 2002 Assistent Molekularbiologie (Dermatologie), Massachusetts General Hospital und Instructor, Harvard Medical School, Massachusetts General Hospital, Boston, USA

2002 – 2004 Sofja-Kovalevskaja-Preisträger, Unabhängiger Gruppenleiter am Zentrum für Biochemie, Universität zu Köln

2004 – 2009 Professor (C3), Klinik für Dermatologie und Zentrum für Biochemie

2009 W3-Professur für Geweberegeneration, Albert-Ludwigs-Universität Freiburg (abgelehnt)

2009 – Professor (W2) für Zahnmedizinische Forschung und Muskuloskelettale Biologie, Medizinische Fakultät, Universität zu Köln, Direktor

Preise und Ehrungen

2002 Sofja-Kovalevskaja-Preis der Alexander von Humboldt-Stiftung und des Bundesministeriums für Bildung und Forschung

Ausgewählte Publikationen

  1. Hamdorf M, Imhof T, Theobald SJ, Simonis A, Di Cristanziano V, Gieselmann L, Dewald F, Lehmann C., Augustin M, Klein F, Alcazar MAA, Rongisch R, Fabri M, Cursiefen C, Rybniker J, Koch* M, Bock* F. The unique ORF8 protein of SARS-CoV-2 binds to human dendritic cells and induces a cytokine storm. J. Mol. Cell Biol. 2023; Accepted. *Shared senior author
  2. Meier M, Gupta M, Akgül S, McDougall M., Imhof T, Nikodemus D, Reuten R, Moya A, To V, Ferens F, Heide F, Padilla-Meier GP, Kukura P, Huang W, Gerisch B, Mörgelin M, Poole K, Antebi* A, Koch* M, Stetefeld* J. The Dynamic Nature of Netrin-1, the Structural Basis for short-chain Glycosaminoglycan induced Filament Formation. Nat. Comm. 2023; Accepted. *Shared senior author
  3. Theobald SJ, Simonis A, Mudler JM, Gobel U, Acton R, Kohlhas V, Albert MC, Hellmann AM, Malin JJ, Winter S, Hallek M, Walczak H, Nguyen PH, Koch M, Rybniker J. Spleen tyrosine kinase mediates innate and adaptive immune crosstalk in SARS-CoV-2 mRNA vaccination. EMBO Mol Med 2022; 14: e15888.
  4. Reuten R, Zendehroud S, Nicolau M, Fleischhauer L, Laitala A, Kiderlen S, Nikodemus D, Wullkopf L, Nielsen SR, McNeilly S, Prein C, Rafaeva M, Schoof EM, Furtwangler B, Porse BT, Kim H, Won KJ, Sudhop S, Zornhagen KW, Suhr F, Maniati E, Pearce OMT, Koch M, Oddershede LB, Van Agtmael T, Madsen CD, Mayorca-Guiliani AE, Bloch W, Netz RR, Clausen-Schaumann H, Erler JT. Basement membrane stiffness determines metastases formation. Nat. Mater. 2021; 20: 892–903.
  5. Imhof T, Balic A, Heilig J, Chiquet-Ehrismann R, Chiquet M, Niehoff A, Brachvogel B, Thesleff I, Koch M. Pivotal Role of Tenascin-W (-N) in Postnatal Incisor Growth and Periodontal Ligament Remodeling. Front. Immunol. 2020; 11: 608223.
  6. Kreer C, Zehner M, Weber T, Ercanoglu MS, Gieselmann L, Rohde C, Halwe S, Korenkov M, Schommers P, Vanshylla K, Di Cristanziano V, Janicki H, Brinker R, Ashurov A, Krahling V, Kupke A, Cohen-Dvashi H, Koch M, Eckert JM, Lederer S, Pfeifer N, Wolf T, Vehreschild M, Wendtner C, Diskin R, Gruell H, Becker S, Klein F. Longitudinal Isolation of Potent Near-Germline SARS-CoV-2-Neutralizing Antibodies from COVID-19 Patients. Cell 2020; 182: 843-54.
  7. Huyghe A, Furlan G, Ozmadenci D, Galonska C, Charlton J, Gaume X, Combemorel N, Riemenschneider C, Allegre N, Zhang J, Wajda P, Rama N, Vieugue P, Durand I, Brevet M, Gadot N, Imhof T, Merrill BJ, Koch M, Mehlen P, Chazaud C, Meissner A, Lavial F. Netrin-1 promotes naive pluripotency through Neo1 and Unc5b co-regulation of Wnt and MAPK signalling. Nat. Cell Biol. 2020; 22: 389-400.
  8. Grandin M, Meier M, Delcros JG, Nikodemus D, Reuten R, Patel TR, Goldschneider D, Orriss G, Krahn N, Boussouar A, Abes R, Dean Y, Neves D, Bernet A, Depil S, Schneiders F, Poole K, Dante R, Koch* M, Mehlen* P, Stetefeld* J. Structural Decoding of the Netrin-1/UNC5 Interaction and its Therapeutical Implications in Cancers. Cancer Cell 2016; 29: 173-85. *Shared senior author
  9. Reuten R, Patel TR, McDougall M, Rama N, Nikodemus D, Gibert B, Delcros JG, Prein C, Meier M, Metzger S, Zhou Z, Kaltenberg J, McKee KK, Bald T, Tuting T, Zigrino P, Djonov V, Bloch W, Clausen-Schaumann H, Poschl E, Yurchenco PD, Ehrbar M, Mehlen* P, Stetefeld* J, Koch* M. Structural decoding of netrin-4 reveals a regulatory function towards mature basement membranes. Nat. Comm. 2016; 7: 13515. *Shared senior author.
  10. Reuten R, Nikodemus D, Oliveira MB, Patel TR, Brachvogel B, Breloy I, Stetefeld J, Koch M. Maltose-Binding Protein (MBP), a Secretion-Enhancing Tag for Mammalian Protein Expression Systems. Plos One 2016; 11: e0152386.

Patents (issued, licensed)

  1. Hagmann H, Benzing T, Schermer B, Koch M, Matin M. “Vegf dimer molecules and columns comprising a vegf dimer molecule as well as uses, production methods and methods involving the same”. U.S. Patent Application No. 17/906,730, filed September 19, 2022; PCT International Patent Application No.: PCT/EP2021/057019, filed March 18, 2021; European Patent Application No. 20164619.7, filed March 20, 2020.

Projekt­bezogene Publikationen

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